Merck KGaA, Darmstadt, Germany and any of its subsidiaries do not accept liability for any omissions or errors in this message which may arise as a result of E-Mail-transmission or for damages resulting from any unauthorized changes of the content of this message and any attachment thereto. If you have received this transmission in error, please notify the sender immediately and delete the message and any attachment from your system. If you are not the intended recipient, you must not copy this message or attachment or disclose the contents to any other person. This message and any attachment are confidential and may be privileged or otherwise protected from disclosure. The specific statements and endorsements of individuals participating in the discussions are not necessarily those of the PMF or the sponsors of the list. The nature of this service is to provide a medium for communication. If your company would be interested in sponsoring this community, please contact Let them know you saw them on our list and appreciate their support of this service. Please take a second to visit our sponsors' web sites. The PMFList is supported by our sponsors as a service to the scientific community. If environmental monitoring is done on TSA plates with incubation at two temperatures, 30-35C then 20-25C, is it necessary to read the plates before transfer to the next temperature or just to read at the end of total incubation time?

If you are unsure please click the button 'Report suspicious email' Do not open links or attachments unless you recognize the sender of this email. No there's no 'requirement' to read the plates but some firms do an interim read.įrom: The Pharmaceutical Microbiology Forum Email List On Behalf Of Reuven Baum We provide the first evidence that RfH is associated with worse long-term health outcomes compared with TRH.Ĭhronic kidney failure heart failure hypertension mortality myocardial infarction prognosis stroke.Hi Reuven. There was no significant difference in all-cause mortality between those with refractory versus TRH. After adjusting for participant characteristics, individuals with RfH had increased risk for the composite renal outcome across all study years (50% decline in estimated glomerular filtration rate or end-stage renal disease hazard ratio for study years 0-10=1.73 ) and the composite cardiovascular disease outcome during later study years (stroke, myocardial infarction, or congestive heart failure hazard ratio for study years 0-3=1.25, for study years 3-6=1.50 ), and for study years 6-10=2.72 ) when compared with individuals with TRH. A total of 136 (4.3%) individuals were identified with RfH at baseline. Outcome risk was compared using Cox proportional hazards models with time-varying covariates. The hypertensive phenotype (ie, no TRH or RfH, TRH, or RfH) was identified at the baseline visit, and health outcomes were monitored at subsequent visits. RfH and TRH were studied in 3147 hypertensive participants in the CRIC (Chronic Renal Insufficiency Cohort study). However, no studies currently show how health outcomes may worsen upon progression to RfH. Treatment-resistant hypertension (TRH), a less severe form of difficult-to-treat hypertension, has been associated with significantly worse health outcomes. Refractory hypertension (RfH) is a severe phenotype of antihypertension treatment failure.

8 Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL (A.C.R.).

7 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD (M.R.W.).

6 Division of Nephrology, Department of Medicine, Case Western Reserve University, Cleveland, OH (M.R.).

5 Department of Biostatistics, Epidemiology, and Informatics (J.B.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

4 Renal-Electrolyte and Hypertension Division (J.B.C.).3 Division of General Internal Medicine, Hypertension Section, Department of Internal Medicine (V.P., B.A., J.M.F.), Southern Illinois University School of Medicine, Springfield, IL.2 Center for Clinical Research (M.G.B., A.B.), Southern Illinois University School of Medicine, Springfield, IL.1 From the Department of Internal Medicine (M.G.B., A.B.), Southern Illinois University School of Medicine, Springfield, IL.

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